Ketamine Infusions Recommended Reading

Ketamine and Other NMDA Antagonists: Early Clinical Trials and Possible Mechanisms in Depression.

  • Newport DJ, Carpenter LL, McDonald WM, Potash JB, Tohen M, Nemeroff CB; APA Council of Research Task Force on Novel Biomarkers and Treatments.
  • Am J Psychiatry. 2015 Oct;172(10):950-66. doi: 10.1176/appi.ajp.2015.15040465. Review.
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Similar articles Ketamine as a promising prototype for a new generation of rapid-acting antidepressants.

  • Abdallah CG, Averill LA, Krystal JH.
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  • DeWilde KE, Levitch CF, Murrough JW, Mathew SJ, Iosifescu DV.
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Similar articles The use of ketamine as an antidepressant: a systematic review and meta-analysis.

  • Coyle CM, Laws KR.
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  • Andrade C.
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Similar articles Criticisms of drugs in early development for the treatment of depression: what can be improved?

  • Wang SM, Han C, Pae CU.
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Similar articles Ketamine as a potential treatment for suicidal ideation: a systematic review of the literature.

  • Reinstatler L, Youssef NA.
  • Drugs R D. 2015 Mar;15(1):37-43. doi: 10.1007/s40268-015-0081-0. Review.
  • PMID: 25773961 [PubMed – indexed for MEDLINE] Free PMC Article

Similar articles Ketamine as a novel treatment for major depressive disorder and bipolar depression: a systematic review and quantitative meta-analysis.

  • Lee EE, Della Selva MP, Liu A, Himelhoch S.
  • Gen Hosp Psychiatry. 2015 Mar-Apr;37(2):178-84. doi: 10.1016/j.genhosppsych.2015.01.003. Epub 2015 Jan 15. Review.
  • PMID: 25698228 [PubMed – indexed for MEDLINE]

Similar articles Ketamine safety and tolerability in clinical trials for treatment-resistant depression.

  • Wan LB, Levitch CF, Perez AM, Brallier JW, Iosifescu DV, Chang LC, Foulkes A, Mathew SJ, Charney DS, Murrough JW.
  • J Clin Psychiatry. 2015 Mar;76(3):247-52. doi: 10.4088/JCP.13m08852.
  • PMID: 25271445 [PubMed – indexed for MEDLINE]

Similar articles A systematic review and meta-analysis of randomized, double-blind, placebo-controlled trials of ketamine in the rapid treatment of major depressive episodes.

  • McGirr A, Berlim MT, Bond DJ, Fleck MP, Yatham LN, Lam RW.
  • Psychol Med. 2015 Mar;45(4):693-704. doi: 10.1017/S0033291714001603. Epub 2014 Jul 10. Review.
  • PMID: 25010396 [PubMed – indexed for MEDLINE]

Similar articles How does ketamine elicit a rapid antidepressant response?

  • Kavalali ET, Monteggia LM.
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  • Solé B, Jiménez E, Martinez-Aran A, Vieta E.
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  • PMID: 25640673 [PubMed – indexed for MEDLINE]

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  • Dutta A, McKie S, Deakin JF.
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  • Abdallah CG, Sanacora G, Duman RS, Krystal JH.
  • Annu Rev Med. 2015;66:509-23. doi: 10.1146/annurev-med-053013-062946. Epub 2014 Oct 17. Review.
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  • Sanacora G, Schatzberg AF.
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  • Xu J, Lei H.
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  • Sisti D, Segal AG, Thase ME.
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  • Walter M, Li S, Demenescu LR.
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  • Fond G, Loundou A, Rabu C, Macgregor A, Lançon C, Brittner M, Micoulaud-Franchi JA, Richieri R, Courtet P, Abbar M, Roger M, Leboyer M, Boyer L.
  • Psychopharmacology (Berl). 2014 Sep;231(18):3663-76. doi: 10.1007/s00213-014-3664-5. Epub 2014 Jul 20. Review.
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  • Duman RS.
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Similar articles A review of ketamine in affective disorders: current evidence of clinical efficacy, limitations of use and pre-clinical evidence on proposed mechanisms of action.

  • Naughton M, Clarke G, O’Leary OF, Cryan JF, Dinan TG.
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  • Niciu MJ, Henter ID, Luckenbaugh DA, Zarate CA Jr, Charney DS.
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  • Duncan WC Jr, Zarate CA Jr.
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  • Katalinic N, Lai R, Somogyi A, Mitchell PB, Glue P, Loo CK.
  • Aust N Z J Psychiatry. 2013 Aug;47(8):710-27. doi: 10.1177/0004867413486842. Epub 2013 May 9. Review.
  • PMID: 23661785 [PubMed – indexed for MEDLINE]

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  • Salvadore G, Singh JB.
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  • PMID: 23578128 [PubMed – indexed for MEDLINE]

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  • Mathews DC, Zarate CA Jr.
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  • Sienaert P, Lambrichts L, Dols A, De Fruyt J.
  • Bipolar Disord. 2013 Feb;15(1):61-9. doi: 10.1111/bdi.12026. Epub 2012 Nov 27. Review.
  • PMID: 23190379 [PubMed – indexed for MEDLINE]

Similar articles Synaptic mechanisms underlying rapid antidepressant action of ketamine.

  • Kavalali ET, Monteggia LM.
  • Am J Psychiatry. 2012 Nov;169(11):1150-6. Review.
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Similar articles Ketamine for depression: where do we go from here?

  • Aan Het Rot M, Zarate CA Jr, Charney DS, Mathew SJ.
  • Biol Psychiatry. 2012 Oct 1;72(7):537-47. doi: 10.1016/j.biopsych.2012.05.003. Epub 2012 Jun 16. Review.
  • PMID: 22705040 [PubMed – indexed for MEDLINE] Free PMC Article

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  • Mathew SJ, Shah A, Lapidus K, Clark C, Jarun N, Ostermeyer B, Murrough JW.
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  • PMID: 22303887 [PubMed – indexed for MEDLINE] Free PMC Article

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  • Murrough JW.
  • Clin Pharmacol Ther. 2012 Feb;91(2):303-9. doi: 10.1038/clpt.2011.244. Epub 2011 Dec 28. Review.
  • PMID: 22205190 [PubMed – indexed for MEDLINE] Free PMC Article

Similar articles Intravenous ketamine for treatment-resistant major depressive disorder.

  • Covvey JR, Crawford AN, Lowe DK.
  • Ann Pharmacother. 2012 Jan;46(1):117-23. doi: 10.1345/aph.1Q371. Epub 2011 Dec 20. Review.
  • PMID: 22190250 [PubMed – indexed for MEDLINE]

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  • Zhao J, Wang Y, Wang D.
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  • Wilkinson ST, Ballard ED, Bloch MH, Mathew SJ, Murrough JW, Feder A, Sos P, Wang G, Zarate CA Jr, Sanacora G.
  • Am J Psychiatry. 2018 Feb 1;175(2):150-158. doi: 10.1176/appi.ajp.2017.17040472. Epub 2017 Oct 3. Review.
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  • Allen CA, Ivester JR Jr.
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Similar articles A Consensus Statement on the Use of Ketamine in the Treatment of Mood Disorders.

  • Sanacora G, Frye MA, McDonald W, Mathew SJ, Turner MS, Schatzberg AF, Summergrad P, Nemeroff CB; American Psychiatric Association (APA) Council of Research Task Force on Novel Biomarkers and Treatments.
  • JAMA Psychiatry. 2017 Apr 1;74(4):399-405. doi: 10.1001/jamapsychiatry.2017.0080. Review.
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Similar articles Efficacy and safety of ketamine in bipolar depression: A systematic review.

  • Alberich S, Martínez-Cengotitabengoa M, López P, Zorrilla I, Núñez N, Vieta E, González-Pinto A.
  • Rev Psiquiatr Salud Ment. 2017 Apr – Jun;10(2):104-112. doi: 10.1016/j.rpsm.2016.05.005.
  • Epub 2016 Jul 5. Review. English, Spanish.
  • PMID: 27387226 [PubMed – indexed for MEDLINE]

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  • Bobo WV, Vande Voort JL, Croarkin PE, Leung JG, Tye SJ, Frye MA.
  • Depress Anxiety. 2016 Aug;33(8):698-710. doi: 10.1002/da.22505. Epub 2016 Apr 6. Review.
  • PMID: 27062450 [PubMed – indexed for MEDLINE]

Similar articles Single-dose infusion ketamine and non-ketamine N-methyl-d-aspartate receptor antagonists for unipolar and bipolar depression: a meta-analysis of efficacy, safety and time trajectories.

  • Kishimoto T, Chawla JM, Hagi K, Zarate CA, Kane JM, Bauer M, Correll CU.
  • Psychol Med. 2016 May;46(7):1459-72. doi: 10.1017/S0033291716000064. Epub 2016 Feb 12.
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  • Xu Y, Hackett M, Carter G, Loo C, Gálvez V, Glozier N, Glue P, Lapidus K, McGirr A, Somogyi AA, Mitchell PB, Rodgers A.
  • Int J Neuropsychopharmacol. 2016 Apr 20;19(4). pii: pyv124. doi: 10.1093/ijnp/pyv124. Print 2016 Apr. Review.
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  • Lee Y, Syeda K, Maruschak NA, Cha DS, Mansur RB, Wium-Andersen IK, Woldeyohannes HO, Rosenblat JD, McIntyre RS.
  • J Clin Psychopharmacol. 2016 Feb;36(1):50-6. doi: 10.1097/JCP.0000000000000441. Review.
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  • Romeo B, Choucha W, Fossati P, Rotge JY.
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  • PMID: 26548981 [PubMed – indexed for MEDLINE]

Similar articles Ketamine and Other NMDA Antagonists: Early Clinical Trials and Possible Mechanisms in Depression.

  • Newport DJ, Carpenter LL, McDonald WM, Potash JB, Tohen M, Nemeroff CB; APA Council of Research Task Force on Novel Biomarkers and Treatments.
  • Am J Psychiatry. 2015 Oct;172(10):950-66. doi: 10.1176/appi.ajp.2015.15040465. Review.
  • PMID: 26423481 [PubMed – indexed for MEDLINE]

Similar articles Ketamine and other glutamate receptor modulators for depression in bipolar disorder in adults.

  • McCloud TL, Caddy C, Jochim J, Rendell JM, Diamond PR, Shuttleworth C, Brett D, Amit BH, McShane R, Hamadi L, Hawton K, Cipriani A.
  • Cochrane Database Syst Rev. 2015 Sep 29;(9):CD011611. doi:
  • 10.1002/14651858.CD011611.pub2. Review.
  • PMID: 26415966 [PubMed – indexed for MEDLINE]

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  • Caddy C, Amit BH, McCloud TL, Rendell JM, Furukawa TA, McShane R, Hawton K, Cipriani A. Cochrane Database Syst Rev. 2015 Sep 23;(9):CD011612. doi:
  • 10.1002/14651858.CD011612.pub2. Review.
  • PMID: 26395901 [PubMed – indexed for MEDLINE]

Similar articles The use of ketamine as an antidepressant: a systematic review and meta-analysis.

  • Coyle CM, Laws KR.
  • Hum Psychopharmacol. 2015 May;30(3):152-63. doi: 10.1002/hup.2475. Epub 2015 Apr 7. Review.
  • PMID: 25847818 [PubMed – indexed for MEDLINE]

Similar articles A systematic review of ketamine for complex regional pain syndrome.

  • Connolly SB, Prager JP, Harden RN.
  • Pain Med. 2015 May;16(5):943-69. doi: 10.1111/pme.12675. Epub 2015 Jan 13. Review.
  • PMID: 25586192 [PubMed – indexed for MEDLINE]

Similar articles Ketamine as a potential treatment for suicidal ideation: a systematic review of the literature.

  • Reinstatler L, Youssef NA.
  • Drugs R D. 2015 Mar;15(1):37-43. doi: 10.1007/s40268-015-0081-0. Review.
  • PMID: 25773961 [PubMed – indexed for MEDLINE] Free PMC Article

Similar articles Ketamine as a novel treatment for major depressive disorder and bipolar depression: a systematic review and quantitative meta-analysis.

  • Lee EE, Della Selva MP, Liu A, Himelhoch S.
  • Gen Hosp Psychiatry. 2015 Mar-Apr;37(2):178-84. doi: 10.1016/j.genhosppsych.2015.01.003.
  • Epub 2015 Jan 15. Review.
  • PMID: 25698228 [PubMed – indexed for MEDLINE]

Similar articles Ketamine safety and tolerability in clinical trials for treatment-resistant depression.

  • Wan LB, Levitch CF, Perez AM, Brallier JW, Iosifescu DV, Chang LC, Foulkes A, Mathew SJ, Charney DS, Murrough JW.
  • J Clin Psychiatry. 2015 Mar;76(3):247-52. doi: 10.4088/JCP.13m08852.
  • PMID: 25271445 [PubMed – indexed for MEDLINE]

Similar articles A systematic review and meta-analysis of randomized, double-blind, placebo-controlled trials of ketamine in the rapid treatment of major depressive episodes.

  • McGirr A, Berlim MT, Bond DJ, Fleck MP, Yatham LN, Lam RW.
  • Psychol Med. 2015 Mar;45(4):693-704. doi: 10.1017/S0033291714001603. Epub 2014 Jul 10. Review.
  • PMID: 25010396 [PubMed – indexed for MEDLINE]

Similar articles Ketamine administration in depressive disorders: a systematic review and meta-analysis.

  • Fond G, Loundou A, Rabu C, Macgregor A, Lançon C, Brittner M, Micoulaud-Franchi JA, Richieri R, Courtet P, Abbar M, Roger M, Leboyer M, Boyer L.
  • Psychopharmacology (Berl). 2014 Sep;231(18):3663-76. doi: 10.1007/s00213-014-3664-5.
  • Epub 2014 Jul 20. Review.
  • PMID: 25038867 [PubMed – indexed for MEDLINE]

Similar articles A review of ketamine in affective disorders: current evidence of clinical efficacy, limitations of use and pre-clinical evidence on proposed mechanisms of action.

  • Naughton M, Clarke G, O’Leary OF, Cryan JF, Dinan TG.
  • J Affect Disord. 2014 Mar;156:24-35. doi: 10.1016/j.jad.2013.11.014. Epub 2013 Dec 10. Review.
  • PMID: 24388038 [PubMed – indexed for MEDLINE]

Similar articles Ketamine in pain management.

  • Persson J.
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Similar articles Ketamine as a fast-acting antidepressant: current knowledge and open questions.

  • Salvadore G, Singh JB.
  • CNS Neurosci Ther. 2013 Jun;19(6):428-36. doi: 10.1111/cns.12103. Epub 2013 Apr 12. Review.
  • PMID: 23578128 [PubMed – indexed for MEDLINE]

Similar articles Ketamine for depression: where do we go from here?

  • Aan Het Rot M, Zarate CA Jr, Charney DS, Mathew SJ.
  • Biol Psychiatry. 2012 Oct 1;72(7):537-47. doi: 10.1016/j.biopsych.2012.05.003. Epub 2012 Jun 16. Review.
  • PMID: 22705040 [PubMed – indexed for MEDLINE] Free PMC Article

Similar articles Rapid-acting antidepressant strategies: mechanisms of action.

  • Bunney BG, Bunney WE.
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  • Epub 2011 Jul 7. Review.
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  • PMID: 22136149 [PubMed – indexed for MEDLINE]

Similar articles Intravenous ketamine for treatment-resistant major depressive disorder.

  • Covvey JR, Crawford AN, Lowe DK.
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